Nootropics News Hubb
Advertisement Banner
  • Home
  • News
  • Neuroscience
  • Creative Thinking
  • Food & Supplements
  • Contact
No Result
View All Result
  • Home
  • News
  • Neuroscience
  • Creative Thinking
  • Food & Supplements
  • Contact
No Result
View All Result
Wellnessnewshubb
No Result
View All Result
Home Neuroscience

Neurologic Improvement in Acute Cerebral Ischemia: Frequency, Magnitude, Predictors, and Clinical Outcomes

admin by admin
March 9, 2023
in Neuroscience



Background and Objectives

Investigations of rapid neurologic improvement (RNI) in patients with acute cerebral ischemia (ACI) have focused on RNI occurring after hospital arrival. However, with stroke routing decisions and interventions increasingly migrating to the prehospital setting, there is a need to delineate the frequency, magnitude, predictors, and clinical outcomes of patients with ACI with ultra-early RNI (U-RNI) in the prehospital and early postarrival period.

Methods

We analyzed prospectively collected data of the prehospital Field Administration of Stroke Therapy–Magnesium (FAST-MAG) randomized clinical trial. Any U-RNI was defined as improvement by 2 or more points on the Los Angeles Motor Scale (LAMS) score between the prehospital and early post–emergency department (ED) arrival examinations and classified as moderate (2–3 point) or dramatic (4–5 point) improvement. Outcome measures included excellent recovery (modified Rankin Scale [mRS] score 0–1) and death by 90 days.

Results

Among the 1,245 patients with ACI, the mean age was 70.9 years (SD 13.2); 45% were women; the median prehospital LAMS was 4 (interquartile range [IQR] 3–5); the median last known well to ED-LAMS time was 59 minutes (IQR 46–80 minutes), and the median prehospital LAMS to ED-LAMS time was 33 minutes (IQR 28–39 minutes). Overall, any U-RNI occurred in 31%, moderate U-RNI in 23%, and dramatic U-RNI in 8%. Any U-RNI was associated with improved outcomes, including excellent recovery (mRS score 0–1) at 90 days 65.1% (246/378) vs 35.4% (302/852), p < 0.0001; decreased mortality by 90 days 3.7% (14/378) vs 16.4% (140/852), p < 0.0001; decreased symptomatic intracranial hemorrhage 1.6% (6/384) vs 4.6% (40/861), p = 0.0112; and increased likelihood of being discharged home 56.8% (218/384) vs 30.2% (260/861), p < 0.0001.

Discussion

U-RNI occurs in nearly 1 in 3 ambulance-transported patients with ACI and is associated with excellent recovery and decreased mortality at 90 days. Accounting for U-RNI may be useful for routing decisions and future prehospital interventions.

Trial Registration Information

clinicaltrials.gov. Unique identifier: NCT00059332.



Source link

Previous Post

Maternal ART throughout gestation prevents caudate volume reductions in neonates who are HIV exposed but uninfected

Next Post

Can You Ever Stop Loving Someone? 11 Steps To Move On

Next Post

Can You Ever Stop Loving Someone? 11 Steps To Move On

Recommended

27 Signs of a Weak Man in a Relationship 

2 months ago

How to Meet New People to Be Successful in Work and Life

2 months ago

Teaching Video NeuroImage: Subacute Cerebellar Ataxia in an Adolescent With Antibodies Against Metabotropic Glutamate Receptor Type 1

4 months ago

A Burned-Out CEO Turns a Ranch into a Retreat

2 months ago

Immune signals that contribute to addiction vulnerability identified in the brain

13 hours ago

Stash RT kit hides a ratcheting wrench inside your bike’s steerer tube

2 months ago

© 2022 Nootropics News Hubb All rights reserved.

Use of these names, logos, and brands does not imply endorsement unless specified. By using this site, you agree to the Privacy Policy and Terms & Conditions.

Navigate Site

  • Home
  • News
  • Neuroscience
  • Creative Thinking
  • Food & Supplements
  • Contact

Newsletter Sign Up.

No Result
View All Result
  • Home
  • News
  • Neuroscience
  • Creative Thinking
  • Food & Supplements
  • Contact

© 2022 Nootropics News Hubb All rights reserved.