Frontera et al. found that less than 20% of patients in their cohort had normal metric scores at 12 months after severe COVID-19 onset. The patients with neurologic complications proceeded to worsen. It was interesting to note that abnormal cognition scores were considerably higher than Barthel Index rates of independent daily living.1 Douaud et al.2 found that after COVID-19, there is a significant reduction in gray matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus and a global brain size reduction, which might explain lasting cognitive deficits.
