Brain Metabolic Profile in Presymptomatic GRN Carriers Throughout a 5-Year Follow-up

From the Sorbonne Université (D.S., L.S., M.H., A.F., D.R., M.L., R.M., I.L.B.), Paris Brain Institute—Institut du Cerveau—ICM, Inserm U1127, CNRS UMR 7225, Paris, France; IM2A (D.S., M.H., A.F., D.R., C.A., R.M., I.L.B.), Reference Centre for Rare or Early-Onset Dementias, Département de Neurologie, AP-HP – Hôpital Pitié-Salpêtrière, Paris, France; Aramis Project Team (D.S.), Inria Research Center of Paris, France; Sorbonne Université (H.B., M.P.-I., M.L., A.K., M.-O.H.), CNRS, INSERM, Laboratoire d’Imagerie Biomédicale, LIB, Paris, France; Centre d’Acquisition et de Traitement d’Images (CATI) (H.B., M.L., A.K., M.-O.H.), US52-UAR2031, CEA, ICM, SU, CNRS, INSERM, APHP, Ile de France, France; Université Paris-Saclay (H.B.), CEA, CNRS, Neurospin, UMR9027 Baobab, Gif-sur-Yvette, France; Centre of Excellence of Neurodegenerative Disease (CoEN) (M.H.), AP-HP – Hôpital Pitié-Salpêtrière, Paris, France; Département de Médecine Nucléaire (V.C.-L., A.K., M.-O.H.), AP-HP – Hôpital Pitié-Salpêtrière, Paris, France; Nuclear Medicine Department (A.J.), CHU Lille, Lille, France; Univ Lille (F.P.), Inserm U1172, CHU Lille, DistAlz, LiCEND, CNR-MAJ, France; Department of Nuclear Medicine (M.C.), Centre Henri Becquerel, Rouen University Hospital, France; Normandie Univ (D.W.), UNIROUEN, Inserm U1245 and CHU Rouen, Department of Neurology, CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, CIC-CRB1404, Rouen, France; Nuclear Medicine Department (A.H.), Toulouse Purpan University Hospital, France; Department of Neurology and ToNIC (J.P.), Toulouse NeuroImaging Centre, Inserm, UPS, Toulouse University Hospital, France; Nuclear Medicine Department (A.P.), University Hospital of Nantes, France; CHU Nantes (C.B.-B.), Inserm CIC04, Department of Neurology, Centre Mémoire de Ressources et Recherche, Nantes, France; Nuclear Medicine Department (E.G.), Aix-Marseille University, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, France; APHM (M.D.), Timone, Service de Neurologie et Neuropsychologie, APHM—Hôpital Timone Adultes, Marseille, France; and Aix-Marseille Univ (M.D.), INSERM, INS Institut de Neurosciences des Systèmes, France.