A 51-year-old woman presented with fever and loss of consciousness for 4 days. Images showed symmetrical lesions in bilateral cortex, limbic system, and basal ganglia (Figure). CSF analysis suggested viral infection. Next-generation sequencing identified 349 unique sequence reads for pseudorabies virus (PRV). She was diagnosed with PRV encephalitis. Epidemiologic survey revealed she was a pork dealer. PRV, also called Suid herpesvirus-1, primarily infects swine. It is reported that PRV can cause human infection through infected swine or pork.1,2 This case suggests unexplained severe encephalitis with similar MRI, and a history of relevant exposure should consider the possibility of PRV infection.
This study was funded by the National Natural Science Foundation of China (No. 81701661), Science and Technology planning project of the Chongqing Clinical Research Centre of Imaging and Nuclear Medicine (No. CSTC2015YFPT-gcjsyjzx0175), and Clinical Medical Research Talents Project of the Army Medical University (2019XLC3049).
The authors report no disclosures relevant to the manuscript. Go to Neurology.org/N for full disclosures.
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
↵* These authors contributed equally to this work.
Submitted and externally peer reviewed. The handling editor was Roy Strowd III, MD, Med, MS.
- Received November 30, 2021.
- Accepted in final form May 5, 2022.
- © 2022 American Academy of Neurology